How does the Nexplanon implant work?

Primary mode of action of Nexplanon: inhibits ovulation

The Nexplanon implant inhibits ovulation as its primary mode of action.^{1, 10} To achieve this reversible inhibition of ovulation,^{6, 10} the contraceptive implant has been designed to slowly release the progestogen etonogestrel for up to 3 years. The release rate of etonogestrel is approximately 60–70 µg/day in the first 5–6 weeks, decreasing to 35–45 µg/day by the end of the first year of use, to 30–40 µg/day by the end of the second year and to 25–30 µg/day by the end of the third year.¹

Secondary mode of action of Nexplanon: effects on cervical mucus and endometrium

In addition to inhibiting ovulation, the Nexplanon implant increases the viscosity of the cervical mucus, which helps to inhibit sperm migration within the female reproductive tract. This important additional effect on cervical mucus contributes to the contraceptive efficacy of the progestogen-only contraceptive. Nexplanon also decreases the thickness of the endometrium making implantation of any ova that should be released and fertilised more difficult.⁹

Request a visit from a Schering-Plough representative to learn more about Nexplanon, including how to train to insert and remove the contraceptive implant.

Information for the general public about the contraceptive implant, Nexplanon.

Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk.
Adverse events should also be reported to MSD Drug Safety Department on 01707 363773

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Date of Preparation 6/2011
Code 6/12 - NEX.10.GB.9260.AVc

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